Nighttime Behaviors related to onset of MCI/Dementia and change in cognition  

 
   Lead Investigator:    Steve Hawes
   Institution      :    NACC
   E-Mail           :    hawes@uw.edu
   Proposal ID      :    516



   Proposal Description:
   Background: Sleep disturbances commonly occur in patients with dementia, and the intensity of these problems increases with severity of dementia.  Sleep problems may occur very early in the course of AD, as the brain regions involved in sleep and circadian rhythm control are affected early in the pathogenesis of disease.  Changes in sleep patterns may precede onset of cognitive symptoms but the time course of changes in sleep from preclinical AD to clinical dementia remains uncertain.  Objective:  To assess patterns of abnormal nighttime behaviors in subjects with normal cognition at baseline who do and do not progress to MCI and/or dementia.  Design:  Cohort study of subjects with follow-up (2+ visits) with and without sleep disturbances.  Subjects would have normal cognition at baseline.  Restrict to subjects aged 65 and older.  UDS only.  Exposure:  Presence (NITE) and severity (NITESEV) of abnormal nighttime behaviors as recorded on NPI-Q (B5).  Outcomes:  development of MCI/dementia, changes in MMSE.  Factors of interest:  Age, sex, education, race, symptoms from NPI-Q, APOE4, CDR scores, B9 info, MMSE, D1 clinical dx.